Cargando…

Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

BACKGROUND: The treatment of traumatic brain injury (TBI) represents an unmet medical need, as no effective pharmacological treatment currently exists. The development of such a treatment requires a fundamental understanding of the pathophysiological mechanisms that underpin the sequelae resulting f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baratz, Renana, Tweedie, David, Wang, Jia-Yi, Rubovitch, Vardit, Luo, Weiming, Hoffer, Barry J, Greig, Nigel H, Pick, Chaim G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352276/ https://www.ncbi.nlm.nih.gov/pubmed/25879458 http://dx.doi.org/10.1186/s12974-015-0237-4

Ejemplares similares

Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-α
por: Rachmany, Lital, et al.
Publicado: (2013)

Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration
por: Rachmany, Lital, et al.
Publicado: (2017)

Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury
por: Bader, Miaad, et al.
Publicado: (2020)

Restoring GM1 ganglioside expression ameliorates axonal outgrowth inhibition and cognitive impairments induced by blast traumatic brain injury
por: Rubovitch, Vardit, et al.
Publicado: (2017)

GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injury
por: Benady, Amit, et al.
Publicado: (2018)

Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild Traumatic Brain Injury (mTBI)
por: Baratz-Goldstein, Renana, et al.
Publicado: (2016)

Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms
por: Tweedie, David, et al.
Publicado: (2016)

No Significant Effects of Cellphone Electromagnetic Radiation on Mice Memory or Anxiety: Some Mixed Effects on Traumatic Brain Injured Mice
por: Qubty, Doaa, et al.
Publicado: (2021)

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat
por: Wang, Jin-Ya, et al.
Publicado: (2016)

Nano-PSO Administration Attenuates Cognitive and Neuronal Deficits Resulting from Traumatic Brain Injury
por: Qubty, Doaa, et al.
Publicado: (2022)

Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat
por: Wang, Jing-Ya, et al.
Publicado: (2016)

Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury
por: Tweedie, David, et al.
Publicado: (2020)

Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury
por: Eakin, Katharine, et al.
Publicado: (2014)

Ketogenic Diet as a potential treatment for traumatic brain injury in mice
por: Har-Even, Meirav, et al.
Publicado: (2021)

Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine
por: Hoffer, Barry J., et al.
Publicado: (2017)

Contextual fear response is modulated by M-type K+ channels and is associated with subtle structural changes of the axon initial segment in hippocampal GABAergic neurons
por: Ruiz, Sara Arciniegas, et al.
Publicado: (2023)

Cognitive and Cellular Effects of Combined Organophosphate Toxicity and Mild Traumatic Brain Injury
por: Freidin, Dor, et al.
Publicado: (2023)

Effect of mild blast-induced TBI on dendritic architecture of the cortex and hippocampus in the mouse
por: Ratliff, Whitney A., et al.
Publicado: (2020)

Exendin-4 Ameliorates Traumatic Brain Injury-Induced Cognitive Impairment in Rats
por: Eakin, Katharine, et al.
Publicado: (2013)

(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice
por: Hsueh, Shih-Chang, et al.
Publicado: (2019)

Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6′-Dithiothalidomide on Traumatic Brain Injury
por: Batsaikhan, Buyandelger, et al.
Publicado: (2019)

3,6′-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Brain Injury
por: Huang, Pen-Sen, et al.
Publicado: (2021)

(−)‐Phenserine tartrate (PhenT) as a treatment for traumatic brain injury
por: Greig, Nigel H., et al.
Publicado: (2019)

Pomalidomide Ameliorates H(2)O(2)-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects
por: Tsai, Yan-Rou, et al.
Publicado: (2018)

Activity of a Novel Anti-Inflammatory Agent F-3,6′-dithiopomalidomide as a Treatment for Traumatic Brain Injury
por: Hsueh, Shih Chang, et al.
Publicado: (2022)

3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation
por: Lin, Chih-Tung, et al.
Publicado: (2020)

Amelioration of Acute Sequelae of Blast Induced Mild Traumatic Brain Injury by N-Acetyl Cysteine: A Double-Blind, Placebo Controlled Study
por: Hoffer, Michael E., et al.
Publicado: (2013)

Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation
por: Tweedie, David, et al.
Publicado: (2011)

Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats
por: Yu, Yu-Wen, et al.
Publicado: (2016)

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury
por: Lecca, Daniela, et al.
Publicado: (2023)

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
por: Belarbi, Karim, et al.
Publicado: (2012)

Drug Repurposing in the Treatment of Traumatic Brain Injury
por: Ghiam, Michael K., et al.
Publicado: (2021)

The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
por: Glotfelty, Elliot J., et al.
Publicado: (2023)

Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam
por: Chen, Yuan-Hao, et al.
Publicado: (2018)

Thrombin as Key Mediator of Seizure Development Following Traumatic Brain Injury
por: Ben Shimon, Marina, et al.
Publicado: (2020)

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
por: Tweedie, David, et al.
Publicado: (2012)

Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments
por: Jung, Yoo Jin, et al.
Publicado: (2019)

Lower Lip Necrosis
por: Lanteri, Alexis, et al.
Publicado: (2012)

Necrosis of the Lower Jaw
por: Smull, W. G.
Publicado: (1855)

Necrosis of Lower Jaw
Publicado: (1863)

Cannot write session to /tmp/vufind_sessions/sess_iued5bhagfr7n4tofdptsnra9n