Identification of a novel type of small molecule inhibitor against HIV-1

Here we report a new chemical inhibitor against HIV-1 with a novel structure and mode of action. The inhibitor, designated as A1836, inhibited HIV-1 replication and virus production with a 50% inhibitory concentration (IC(50)) of 2.0 μM in an MT-4 cell-based and cytopathic protection antiviral assay...

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Detalles Bibliográficos
Autores principales: Kim, Byung Soo, Park, Jung Ae, Kim, Min-Jung, Kim, Seon Hee, Yu, Kyung Lee, You, Ji Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2015
Materias:
Research-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352614/
https://www.ncbi.nlm.nih.gov/pubmed/25413304
http://dx.doi.org/10.5483/BMBRep.2015.48.2.239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352614/
https://www.ncbi.nlm.nih.gov/pubmed/25413304
http://dx.doi.org/10.5483/BMBRep.2015.48.2.239

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