Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

Subunit vaccines comprised of glycoprotein D (gD-2) failed to prevent HSV-2 highlighting need for novel strategies. To test the hypothesis that deletion of gD-2 unmasks protective antigens, we evaluated the efficacy and safety of an HSV-2 virus deleted in gD-2 and complemented allowing a single roun...

Descripción completa

Detalles Bibliográficos
Autores principales: Petro, Christopher, González, Pablo A, Cheshenko, Natalia, Jandl, Thomas, Khajoueinejad, Nazanin, Bénard, Angèle, Sengupta, Mayami, Herold, Betsy C, Jacobs, William R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352706/
https://www.ncbi.nlm.nih.gov/pubmed/25756612
http://dx.doi.org/10.7554/eLife.06054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352706/
https://www.ncbi.nlm.nih.gov/pubmed/25756612
http://dx.doi.org/10.7554/eLife.06054

Ejemplares similares