DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through...

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Detalles Bibliográficos
Autores principales: Papp, Stephanie J, Huber, Anne-Laure, Jordan, Sabine D, Kriebs, Anna, Nguyen, Madelena, Moresco, James J, Yates, John R, Lamia, Katja A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352707/
https://www.ncbi.nlm.nih.gov/pubmed/25756610
http://dx.doi.org/10.7554/eLife.04883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352707/
https://www.ncbi.nlm.nih.gov/pubmed/25756610
http://dx.doi.org/10.7554/eLife.04883

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