Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

Deubiquitinating enzymes (DUBs) control vital processes in eukaryotes by hydrolyzing ubiquitin adducts. Their activities are tightly regulated, but the mechanisms remain elusive. In particular, the DUB UCH-L5 can be either activated or inhibited by conserved regulatory proteins RPN13 and INO80G, res...

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Detalles Bibliográficos
Autores principales: Sahtoe, Danny D., van Dijk, Willem J., El Oualid, Farid, Ekkebus, Reggy, Ovaa, Huib, Sixma, Titia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352763/
https://www.ncbi.nlm.nih.gov/pubmed/25702870
http://dx.doi.org/10.1016/j.molcel.2014.12.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352763/
https://www.ncbi.nlm.nih.gov/pubmed/25702870
http://dx.doi.org/10.1016/j.molcel.2014.12.039

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