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Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G
Deubiquitinating enzymes (DUBs) control vital processes in eukaryotes by hydrolyzing ubiquitin adducts. Their activities are tightly regulated, but the mechanisms remain elusive. In particular, the DUB UCH-L5 can be either activated or inhibited by conserved regulatory proteins RPN13 and INO80G, res...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352763/ https://www.ncbi.nlm.nih.gov/pubmed/25702870 http://dx.doi.org/10.1016/j.molcel.2014.12.039 |