Differential Control of Heme Reactivity in Alpha and Beta Subunits of Hemoglobin: A Combined Raman Spectroscopic and Computational Study

[Image: see text] The use of hybrid hemoglobin (Hb), with mesoheme substituted for protoheme, allows separate monitoring of the α or β hemes along the allosteric pathway. Using resonance Raman (rR) spectroscopy in silica gel, which greatly slows protein motions, we have observed that the Fe–histidin...

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Detalles Bibliográficos
Autores principales: Jones, Eric M., Monza, Emanuele, Balakrishnan, Gurusamy, Blouin, George C., Mak, Piotr J., Zhu, Qianhong, Kincaid, James R., Guallar, Victor, Spiro, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353013/
https://www.ncbi.nlm.nih.gov/pubmed/24991732
http://dx.doi.org/10.1021/ja503328a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353013/
https://www.ncbi.nlm.nih.gov/pubmed/24991732
http://dx.doi.org/10.1021/ja503328a

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