Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity

The 6-phosphogluconate dehydrogenase superfamily oxidize and reduce a wide range of substrates, making their functional annotation challenging. Ketol-acid reductoisomerase (KARI), encoded by the ilvC gene in branched-chain amino acids biosynthesis, is a promiscuous reductase enzyme within this super...

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Detalles Bibliográficos
Autores principales: Verdel-Aranda, Karina, López-Cortina, Susana T, Hodgson, David A, Barona-Gómez, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353338/
https://www.ncbi.nlm.nih.gov/pubmed/25296650
http://dx.doi.org/10.1111/1751-7915.12175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353338/
https://www.ncbi.nlm.nih.gov/pubmed/25296650
http://dx.doi.org/10.1111/1751-7915.12175

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