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Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity

The 6-phosphogluconate dehydrogenase superfamily oxidize and reduce a wide range of substrates, making their functional annotation challenging. Ketol-acid reductoisomerase (KARI), encoded by the ilvC gene in branched-chain amino acids biosynthesis, is a promiscuous reductase enzyme within this super...

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Detalles Bibliográficos
Autores principales:	Verdel-Aranda, Karina, López-Cortina, Susana T, Hodgson, David A, Barona-Gómez, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353338/ https://www.ncbi.nlm.nih.gov/pubmed/25296650 http://dx.doi.org/10.1111/1751-7915.12175

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