Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate the hypothesis that reactivation of plasticity can restore function in the presence of neuronal damage resulting from tauopathy. We investigated two models with tau hyperphosphorylation, aggregation and ne...

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Detalles Bibliográficos
Autores principales: Yang, Sujeong, Cacquevel, Matthias, Saksida, Lisa M., Bussey, Timothy J., Schneider, Bernard L., Aebischer, Patrick, Melani, Riccardo, Pizzorusso, Tommaso, Fawcett, James W., Spillantini, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353684/
https://www.ncbi.nlm.nih.gov/pubmed/25483398
http://dx.doi.org/10.1016/j.expneurol.2014.11.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353684/
https://www.ncbi.nlm.nih.gov/pubmed/25483398
http://dx.doi.org/10.1016/j.expneurol.2014.11.013

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