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Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration

Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated administration of cisplatin. In this study, we as...

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Detalles Bibliográficos
Autores principales: Kenward, Hannah, Pelligand, Ludovic, Elliott, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353862/
https://www.ncbi.nlm.nih.gov/pubmed/24792501
http://dx.doi.org/10.1007/s00221-014-3961-6