Kinetic gating mechanism of DNA damage recognition by Rad4/XPC

The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC ortholog...

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Detalles Bibliográficos
Autores principales: Chen, Xuejing, Velmurugu, Yogambigai, Zheng, Guanqun, Park, Beomseok, Shim, Yoonjung, Kim, Youngchang, Liu, Lili, Van Houten, Bennett, He, Chuan, Ansari, Anjum, Min, Jung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354021/
https://www.ncbi.nlm.nih.gov/pubmed/25562780
http://dx.doi.org/10.1038/ncomms6849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354021/
https://www.ncbi.nlm.nih.gov/pubmed/25562780
http://dx.doi.org/10.1038/ncomms6849

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