Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours

Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate that hair follicle bulge stem cells (SCs) give rise to well-differentiated sebaceous tumours and show that SCs are not only cruci...

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Detalles Bibliográficos
Autores principales: Petersson, Monika, Reuter, Karen, Brylka, Heike, Kraus, Andreas, Schettina, Peter, Niemann, Catherin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354047/
https://www.ncbi.nlm.nih.gov/pubmed/25608467
http://dx.doi.org/10.1038/ncomms6874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354047/
https://www.ncbi.nlm.nih.gov/pubmed/25608467
http://dx.doi.org/10.1038/ncomms6874

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