Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

The rd1 mouse with a mutation in the Pde6b gene was the first strain of mice identified with a retinal degeneration. However, AAV-mediated gene supplementation of rd1 mice only results in structural preservation of photoreceptors, and restoration of the photoreceptor-mediated a-wave, but not in rest...

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Detalles Bibliográficos
Autores principales: Nishiguchi, Koji M., Carvalho, Livia S., Rizzi, Matteo, Powell, Kate, Holthaus, Sophia-Martha kleine, Azam, Selina A., Duran, Yanai, Ribeiro, Joana, Luhmann, Ulrich F. O., Bainbridge, James W. B., Smith, Alexander J., Ali, Robin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354202/
https://www.ncbi.nlm.nih.gov/pubmed/25613321
http://dx.doi.org/10.1038/ncomms7006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354202/
https://www.ncbi.nlm.nih.gov/pubmed/25613321
http://dx.doi.org/10.1038/ncomms7006

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