Cargando…

Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB

According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide (LSP)-stimulated BV2 microglial cells. Shikonin dose-depe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prasad, Rajapaksha Gedara, Choi, Yung Hyun, Kim, Gi-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354311/ https://www.ncbi.nlm.nih.gov/pubmed/25767678 http://dx.doi.org/10.4062/biomolther.2015.006

Ejemplares similares

Exploring the evolutionary process of alkannin/shikonin O-acyltransferases by a reliable Lithospermum erythrorhizon genome
por: Tang, Chengyi
Publicado: (2021)

Involvement of LeMDR, an ATP-binding cassette protein gene, in shikonin transport and biosynthesis in Lithospermum erythrorhizon
por: Zhu, Yu, et al.
Publicado: (2017)

Genome-Wide Comparison and Functional Characterization of HMGR Gene Family Associated with Shikonin Biosynthesis in Lithospermum erythrorhizon
por: Wang, Xuan, et al.
Publicado: (2023)

Hybrid de novo genome assembly of red gromwell (Lithospermum erythrorhizon) reveals evolutionary insight into shikonin biosynthesis
por: Auber, Robert P., et al.
Publicado: (2020)

Transgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots
por: Fang, Rongjun, et al.
Publicado: (2016)

Characterization of Shikonin Derivative Secretion in Lithospermum erythrorhizon Hairy Roots as a Model of Lipid-Soluble Metabolite Secretion from Plants
por: Tatsumi, Kanade, et al.
Publicado: (2016)

Protective Effects of Lithospermum erythrorhizon Against Cerulein-Induced Acute Pancreatitis
por: Choi, Sun Bok, et al.
Publicado: (2015)

Glutamine Cooperatively Upregulates Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglial Cells through the ERK and Nrf-2/HO-1 Signaling Pathway
por: Jayasooriya, Rajapaksha Gedara Prasad Tharanga, et al.
Publicado: (2020)

Single- and Repeat-dose Oral Toxicity Studies of Lithospermum erythrorhizon Extract in Dogs
por: Nam, Chunja, et al.
Publicado: (2015)

Evidence and Potential Mechanism of Action of Lithospermum erythrorhizon and Its Active Components for Psoriasis
por: Wang, Jiao, et al.
Publicado: (2022)

Network Pharmacology Revealed the Mechanisms of Action of Lithospermum erythrorhizon Sieb on Atopic Dermatitis
por: Wang, Tianyi, et al.
Publicado: (2023)

Deoxynivalenol enhances IL-1ß expression in BV2 microglial cells through activation of the NF-?B pathway and the ASC/NLRP3 inflammasome
por: Molagoda, Ilandarage Menu Neelaka, et al.
Publicado: (2019)

Genome-Wide Identification of LeBAHDs in Lithospermum erythrorhizon and In Vivo Transgenic Studies Confirm the Critical Roles of LeBAHD1/LeSAT1 in the Conversion of Shikonin to Acetylshikonin
por: Wang, Xuan, et al.
Publicado: (2022)

Apple latent spherical virus (ALSV)-induced gene silencing in a medicinal plant, Lithospermum erythrorhizon
por: Izuishi, Yuki, et al.
Publicado: (2020)

Anthocyanins Downregulate Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglial Cells by Suppressing the NF-κB and Akt/MAPKs Signaling Pathways
por: Jeong, Jin-Woo, et al.
Publicado: (2013)

Acute and 28-Day Subacute Toxicity Studies of Hexane Extracts of the Roots of Lithospermum erythrorhizon in Sprague-Dawley Rats
por: Han, Chung-Tack, et al.
Publicado: (2015)

Biosynthesis and Cytotoxic Properties of Ag, Au, and Bimetallic Nanoparticles Synthesized Using Lithospermum erythrorhizon Callus Culture Extract
por: Shkryl, Yury, et al.
Publicado: (2021)

Revealing Potential Bioactive Compounds and Mechanisms of Lithospermum erythrorhizon against COVID-19 via Network Pharmacology Study
por: Oh, Ki-Kwang, et al.
Publicado: (2022)

Inventory of ATP-binding cassette proteins in Lithospermum erythrorhizon as a model plant producing divergent secondary metabolites
por: Li, Hao, et al.
Publicado: (2022)

Antiallergic Effects of N,N-dicoumaroylspermidine Isolated from Lithospermum erythrorhizon on Mast Cells and Ovalbumin-Induced Allergic Rhinitis
por: Le, Tam Thi, et al.
Publicado: (2022)

Dynamics of alkannin/shikonin biosynthesis in response to jasmonate and salicylic acid in Lithospermum officinale
por: Ahmad, Muhammad, et al.
Publicado: (2022)

Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
por: Choi, Doo Jin, et al.
Publicado: (2022)

Protective Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract against Hepatic Steatosis in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mice
por: Choi, Doo Jin, et al.
Publicado: (2020)

Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells
por: Choi, Yung Hyun, et al.
Publicado: (2012)

Transcriptional dynamics of Chitinophaga sp. strain R-73072-mediated alkannin/shikonin biosynthesis in Lithospermum officinale
por: Ahmad, Muhammad, et al.
Publicado: (2022)

Naegleria fowleri Extracellular Vesicles Induce Proinflammatory Immune Responses in BV-2 Microglial Cells
por: Lê, Hương Giang, et al.
Publicado: (2023)

Prunus mume and Lithospermum erythrorhizon Extracts Synergistically Prevent Visceral Adiposity by Improving Energy Metabolism through Potentiating Hypothalamic Leptin and Insulin Signalling in Ovariectomized Rats
por: Ko, Byoung-Seob, et al.
Publicado: (2013)

Inhibition of Lipopolysaccharide-Induced Proinflammatory Responses by Buddleja officinalis Extract in BV-2 Microglial Cells via Negative Regulation of NF-κB and ERK1/2 Signaling
por: Oh, Won-Jun, et al.
Publicado: (2013)

The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide
por: Lim, Hye-Sun, et al.
Publicado: (2018)

Determination of Five Chemical Markers in DF Formula, the Herbal Composition of Ephedra intermedia, Rheum palmatum, and Lithospermum erythrorhizon, Using High-performance Liquid Chromatography-ultraviolet Detection
por: Jeong, Birang, et al.
Publicado: (2018)

Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice
por: Oh, Jin-Su, et al.
Publicado: (2021)

Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-κB and toll-like receptor pathways in lipopolysaccharide-stimulated BV2 microglial cells
por: YOON, HYUN-MIN, et al.
Publicado: (2013)

Effect of Glycine on BV-2 Microglial Cells Treated with Interferon-γ and Lipopolysaccharide
por: Egger, Florentina, et al.
Publicado: (2020)

Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-κB and ERK Signaling Pathways in BV2 Cells
por: Dang, Yalong, et al.
Publicado: (2014)

Long Noncoding RNA Expression Profile in BV2 Microglial Cells Exposed to Lipopolysaccharide
por: Li, Yajuan, et al.
Publicado: (2019)

Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-κB/p65 pathway
por: Shi, Yong-Xiang, et al.
Publicado: (2020)

Retraction: Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-κB and ERK Signaling Pathways in BV2 Cells
Publicado: (2019)

Spirulina platensis Suppressed iNOS and Proinflammatory Cytokines in Lipopolysaccharide-Induced BV2 Microglia
por: Ngu, Ee-Ling, et al.
Publicado: (2022)

Anti-Inflammatory Effect of Ginsenoside Rg5 in Lipopolysaccharide-Stimulated BV2 Microglial Cells
por: Lee, Yu Young, et al.
Publicado: (2013)

High glucose enhances lipopolysaccharide‐induced inflammation in cultured BV2 microglial cell line
por: Hung, Hao‐Chang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o1c3v702f3r068jpbj457i247h