Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia

Environmental factors have been associated with psychiatric disorders and recent epidemiological studies suggest an association between prenatal lead (Pb(2+)) exposure and schizophrenia (SZ). Pb(2+) is a potent antagonist of the N-methyl-D-aspartate receptor (NMDAR) and converging evidence indicates...

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Detalles Bibliográficos
Autores principales: Stansfield, K H, Ruby, K N, Soares, B D, McGlothan, J L, Liu, X, Guilarte, T R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354343/
https://www.ncbi.nlm.nih.gov/pubmed/25756805
http://dx.doi.org/10.1038/tp.2014.147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354343/
https://www.ncbi.nlm.nih.gov/pubmed/25756805
http://dx.doi.org/10.1038/tp.2014.147

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