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Process development for the production of 15β-hydroxycyproterone acetate using Bacillus megaterium expressing CYP106A2 as whole-cell biocatalyst

BACKGROUND: CYP106A2 from Bacillus megaterium ATCC 13368 was first identified as a regio- and stereoselective 15β-hydroxylase of 3-oxo-∆(4)-steroids. Recently, it was shown that besides 3-oxo-∆(4)-steroids, 3-hydroxy-∆(5)-steroids as well as di- and triterpenes can also serve as substrates for this...

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Detalles Bibliográficos
Autores principales: Kiss, Flora M, Lundemo, Marie T, Zapp, Josef, Woodley, John M, Bernhardt, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354754/
https://www.ncbi.nlm.nih.gov/pubmed/25890176
http://dx.doi.org/10.1186/s12934-015-0210-z