The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

OBJECTIVE: Disruption of TCF7L2 in mouse pancreatic β-cells has generated different outcomes in several investigations. Here we aim to clarify role of β-cell TCF7L2 and Wnt signaling using a functional-knockdown approach. METHODS: Adenovirus-mediated dominant negative TCF7L2 (TCF7L2DN) expression wa...

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Detalles Bibliográficos
Autores principales: Shao, Weijuan, Xiong, Xiaoquan, Ip, Wilfred, Xu, Fenghao, Song, Zhuolun, Zeng, Kejing, Hernandez, Marcela, Liang, Tao, Weng, Jianping, Gaisano, Herbert, Nostro, M. Cristina, Jin, Tianru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354927/
https://www.ncbi.nlm.nih.gov/pubmed/25830097
http://dx.doi.org/10.1016/j.molmet.2015.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354927/
https://www.ncbi.nlm.nih.gov/pubmed/25830097
http://dx.doi.org/10.1016/j.molmet.2015.01.008

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