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Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors
The alpha carbonic anhydrases (α-CAs) are a group of structurally related zinc metalloenzymes that catalyze the reversible hydration of CO(2) to HCO(3) (−). Humans have 15 different α-CAs with numerous physiological roles and expression patterns. Of these, 12 are catalytically active, and abnormal e...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355338/ https://www.ncbi.nlm.nih.gov/pubmed/25811028 http://dx.doi.org/10.1155/2015/453543 |