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Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

The alpha carbonic anhydrases (α-CAs) are a group of structurally related zinc metalloenzymes that catalyze the reversible hydration of CO(2) to HCO(3) (−). Humans have 15 different α-CAs with numerous physiological roles and expression patterns. Of these, 12 are catalytically active, and abnormal e...

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Detalles Bibliográficos
Autores principales:	Pinard, Melissa A., Mahon, Brian, McKenna, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355338/ https://www.ncbi.nlm.nih.gov/pubmed/25811028 http://dx.doi.org/10.1155/2015/453543

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