Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

INTRODUCTION: Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of sclerostin in bone and cartilage in a joint instability model in mice. METHODS: Ten-week-old SOST-k...

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Detalles Bibliográficos
Autores principales: Bouaziz, Wafa, Funck-Brentano, Thomas, Lin, Hilène, Marty, Caroline, Ea, Hang-Korng, Hay, Eric, Cohen-Solal, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355467/
https://www.ncbi.nlm.nih.gov/pubmed/25656376
http://dx.doi.org/10.1186/s13075-015-0540-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355467/
https://www.ncbi.nlm.nih.gov/pubmed/25656376
http://dx.doi.org/10.1186/s13075-015-0540-6

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