Cargando…

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

INTRODUCTION: Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of sclerostin in bone and cartilage in a joint instability model in mice. METHODS: Ten-week-old SOST-k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bouaziz, Wafa, Funck-Brentano, Thomas, Lin, Hilène, Marty, Caroline, Ea, Hang-Korng, Hay, Eric, Cohen-Solal, Martine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355467/ https://www.ncbi.nlm.nih.gov/pubmed/25656376 http://dx.doi.org/10.1186/s13075-015-0540-6

Ejemplares similares

Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice
por: Lin, Hilène, et al.
Publicado: (2018)

Anti-Sclerostin Antibodies in Osteoporosis and Other Bone Diseases
por: Fabre, Stéphanie, et al.
Publicado: (2020)

Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism
por: Funck-Brentano, Thomas, et al.
Publicado: (2012)

Adrenomedullin and truncated peptide adrenomedullin(22-52) affect chondrocyte response to apoptotis in vitro: downregulation of FAS protects chondrocyte from cell death
por: Velard, Frédéric, et al.
Publicado: (2020)

Bone fragility in patients with chronic kidney disease
por: Cohen-Solal, Martine, et al.
Publicado: (2020)

Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice
por: Jouan, Yohan, et al.
Publicado: (2022)

More severe phenotype of early‐onset osteoporosis associated with recessive form of LRP5 and combination with DKK1 or WNT3A
por: Caetano da Silva, Caroline, et al.
Publicado: (2021)

EZH2 inhibition reduces cartilage loss and functional impairment related to osteoarthritis
por: Allas, Lyess, et al.
Publicado: (2020)

Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation
por: Ah Kioon, Marie-Dominique, et al.
Publicado: (2010)

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling
por: van Dinther, Maarten, et al.
Publicado: (2013)

Effects of Wnt-β-Catenin Signaling and Sclerostin on the Phenotypes of Rat Pheochromocytoma PC12 Cells
por: Morimoto, Eisaku, et al.
Publicado: (2022)

Effect of C282Y Genotype on Self-Reported Musculoskeletal Complications in Hereditary Hemochromatosis
por: Camacho, António, et al.
Publicado: (2015)

Chondrocalcinosis of Femoro-Tibial and Proximal Tibio-Fibular Joints in Cadaveric Specimens: A High-Resolution CT Imaging Study of the Calcification Distribution
por: Touraine, Sébastien, et al.
Publicado: (2013)

Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis
por: Nasi, Sonia, et al.
Publicado: (2017)

Bone‐derived sclerostin and Wnt/β‐catenin signaling regulate PDGFRα(+) adipoprogenitor cell differentiation
por: Kim, Soohyun P., et al.
Publicado: (2021)

Sclerostin aggravates cardiac remodeling after myocardial infarction by inhibition of Wnt/β-catenin signaling pathway
por: Zheng, Shuxin, et al.
Publicado: (2022)

Correction: Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis
por: Simão, Márcio, et al.
Publicado: (2019)

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis
por: Simão, Márcio, et al.
Publicado: (2018)

Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice
por: Törnqvist, Anna E., et al.
Publicado: (2020)

Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias
por: Richette, Pascal, et al.
Publicado: (2015)

Wnt-β-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage
por: Wu, Jiang, et al.
Publicado: (2017)

Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis
por: Nasi, Sonia, et al.
Publicado: (2016)

Sclerostin, Osteocytes, and Wnt Signaling in Pediatric Renal Osteodystrophy
por: Laster, Marciana, et al.
Publicado: (2023)

Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis
por: Hafsia, Narjès, et al.
Publicado: (2020)

Sclerostin expression in the subchondral bone of patients with knee osteoarthritis
por: Wu, Long, et al.
Publicado: (2016)

Lrp5 p.Val667Met Variant Compromises Bone Mineral Density and Matrix Properties in Osteoporosis
por: Fabre, Stéphanie, et al.
Publicado: (2023)

Sclerostin inhibits interleukin-1β-induced late stage chondrogenic differentiation through downregulation of Wnt/β-catenin signaling pathway
por: Miyatake, Kazuma, et al.
Publicado: (2020)

Icariin Promotes the Osteogenesis of Bone Marrow Mesenchymal Stem Cells through Regulating Sclerostin and Activating the Wnt/β-Catenin Signaling Pathway
por: Gao, Jianliang, et al.
Publicado: (2021)

Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice
por: Gu, Yanqing, et al.
Publicado: (2019)

Obesity and Bone Loss at Menopause: The Role of Sclerostin
por: Marzullo, Paolo, et al.
Publicado: (2021)

Serum sclerostin is an independent predictor of mortality in hemodialysis patients
por: Gonçalves, Flávia Letícia Carvalho, et al.
Publicado: (2014)

Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways
por: Campillo-Gimenez, Laure, et al.
Publicado: (2018)

The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6
por: Boschert, V., et al.
Publicado: (2016)

Sclerostin
por: Silverman, Stuart L.
Publicado: (2010)

Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice
por: Funck-Brentano, Thomas, et al.
Publicado: (2018)

Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank
por: Funck‐Brentano, Thomas, et al.
Publicado: (2019)

Critical appraisal of the role of pegloticase in the management of gout
por: Ea, Hang-Korng, et al.
Publicado: (2012)

Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
por: Mansouri, Rafik, et al.
Publicado: (2017)

Correction: Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
por: Mansouri, Rafik, et al.
Publicado: (2018)

Wnt/β-catenin signaling may induce senescence of chondrocytes in osteoarthritis
por: Li, Weijun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0es9rg68c2r3p68icbgq83aqjb