Inhibition of Calpain Prevents Manganese-Induced Cell Injury and Alpha-Synuclein Oligomerization in Organotypic Brain Slice Cultures

Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear. To explore whether alpha-synuclein oligomerization was associated with the cleavage of alpha-synuc...

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Detalles Bibliográficos
Autores principales: Xu, Bin, Liu, Wei, Deng, Yu, Yang, Tian-Yao, Feng, Shu, Xu, Zhao-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355489/
https://www.ncbi.nlm.nih.gov/pubmed/25756858
http://dx.doi.org/10.1371/journal.pone.0119205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355489/
https://www.ncbi.nlm.nih.gov/pubmed/25756858
http://dx.doi.org/10.1371/journal.pone.0119205

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