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N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions

RNA-binding proteins control many aspects of cellular biology through binding single-stranded RNA binding motifs (RBM)(1-3). However, RBMs can be buried within their local RNA structures(4-7), thus inhibiting RNA-protein interactions. N(6)-methyladenosine (m(6)A), the most abundant and dynamic inter...

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Detalles Bibliográficos
Autores principales: Liu, Nian, Dai, Qing, Zheng, Guanqun, He, Chuan, Parisien, Marc, Pan, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355918/
https://www.ncbi.nlm.nih.gov/pubmed/25719671
http://dx.doi.org/10.1038/nature14234