Cargando…

Vitamin B(12) insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

BACKGROUND: The dietary supply of methyl donors such as folate, vitamin B(12), betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and animal studies have shown that vitamin B(12) deficiency is associated with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adaikalakoteswari, Antonysunil, Finer, Sarah, Voyias, Philip D, McCarthy, Ciara M, Vatish, Manu, Moore, Jonathan, Smart-Halajko, Melissa, Bawazeer, Nahla, Al-Daghri, Nasser M, McTernan, Philip G, Kumar, Sudhesh, Hitman, Graham A, Saravanan, Ponnusamy, Tripathi, Gyanendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356060/ https://www.ncbi.nlm.nih.gov/pubmed/25763114 http://dx.doi.org/10.1186/s13148-015-0046-8

Ejemplares similares

MON-598 Vitamin B12 Deficiency Leads to Fatty Acid Metabolism Dysregulation and Increased Pro-Inflammatory Cytokine Production in Human Adipocytes and Maternal Subcutaneous and Omental Adipose Tissue
por: Samavat, Jinous, et al.
Publicado: (2020)

Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK
por: Adaikalakoteswari, Antonysunil, et al.
Publicado: (2015)

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro
por: Pushpakom, Sudeep P, et al.
Publicado: (2018)

Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes
por: Adaikalakoteswari, Antonysunil, et al.
Publicado: (2014)

An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes
por: Ogunkolade, B. William, et al.
Publicado: (2021)

Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies
por: Boachie, Joseph, et al.
Publicado: (2020)

High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects
por: Harte, Alison L., et al.
Publicado: (2012)

Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects
por: Al-Daghri, Nasser M., et al.
Publicado: (2016)

Vitamin B(12) status in women of childbearing age in the UK and its relationship with national nutrient intake guidelines: results from two National Diet and Nutrition Surveys
por: Sukumar, Nithya, et al.
Publicado: (2016)

Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids
por: Jackisch, Laura, et al.
Publicado: (2018)

Prevalence and Indicators of Vitamin B12 Insufficiency among Young Women of Childbearing Age
por: Al-Musharaf, Sara, et al.
Publicado: (2020)

Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin
por: Al-Attas, Omar S, et al.
Publicado: (2010)

Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter
por: Boachie, Joseph, et al.
Publicado: (2021)

Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in south-Asians
por: Wasim, Hanif, et al.
Publicado: (2006)

An interview with Philip McTernan, section editor for the basic science section
por: McTernan, Philip G
Publicado: (2014)

Endotoxemia, vitamin D and premature biological ageing in Arab adults with different metabolic states
por: Al-Daghri, Nasser M., et al.
Publicado: (2022)

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies
por: Al-Attas, Omar S, et al.
Publicado: (2009)

Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery
por: Martinez de la Escalera, Lucia, et al.
Publicado: (2017)

Metabolic endotoxaemia in childhood obesity
por: Varma, Madhusudhan C., et al.
Publicado: (2016)

Vitamin B12 deficiency and altered one-carbon metabolites in early pregnancy is associated with maternal obesity and dyslipidaemia
por: Adaikalakoteswari, Antonysunil, et al.
Publicado: (2020)

Visfatin Is Regulated by Rosiglitazone in Type 2 Diabetes Mellitus and Influenced by NFκB and JNK in Human Abdominal Subcutaneous Adipocytes
por: McGee, Kirsty C., et al.
Publicado: (2011)

Response to Comment on: Harte et al. High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects. Diabetes Care 2012;35:375–382
por: Harte, Alison L., et al.
Publicado: (2013)

Postprandial Effect of a High-Fat Meal on Endotoxemia in Arab Women with and without Insulin-Resistance-Related Diseases
por: Al-Disi, Dara A., et al.
Publicado: (2015)

The impact of metabolic endotoxaemia on the browning process in human adipocytes
por: Omran, Farah, et al.
Publicado: (2023)

Tissue-specific changes in Srebf1 and Srebf2 expression and DNA methylation with perinatal phthalate exposure
por: Moody, Laura, et al.
Publicado: (2019)

Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus
por: Harte, Alison L., et al.
Publicado: (2012)

BMC Obesity – expanding the BMC series into an important area of research
por: Horne, Genevieve, et al.
Publicado: (2014)

Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease
por: Baker, Adam R, et al.
Publicado: (2006)

Seminal but not Serum Levels of Holotranscobalamin are Altered in Morbid Obesity and Correlate with Semen Quality: A Pilot Single Centre Study
por: Samavat, Jinous, et al.
Publicado: (2019)

Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial
por: Sabico, Shaun, et al.
Publicado: (2017)

Effects of probiotics in patients with diabetes mellitus type 2: study protocol for a randomized, double-blind, placebo-controlled trial
por: Alokail, Majed S, et al.
Publicado: (2013)

SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population
por: Vargas-Alarcon, Gilberto, et al.
Publicado: (2019)

Regulatory Roles of SREBF1 and SREBF2 in Lipid Metabolism and Deposition in Two Chinese Representative Fat-Tailed Sheep Breeds
por: Liang, Chen, et al.
Publicado: (2020)

Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro()
por: Youssef-Elabd, Elham M., et al.
Publicado: (2012)

Association of maternal vitamin B(12) and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study)
por: Saravanan, Ponnusamy, et al.
Publicado: (2021)

Inflammatory and Adipokine Status from Early to Midpregnancy in Arab Women and Its Associations with Gestational Diabetes Mellitus
por: Al-Musharaf, Sara, et al.
Publicado: (2021)

Gut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetes
por: Al-Daghri, Nasser M., et al.
Publicado: (2021)

Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population
por: Al-Daghri, N, et al.
Publicado: (2005)

High glucose load and endotoxemia among overweight and obese Arab women with and without diabetes: An observational study
por: Al-Disi, Dara, et al.
Publicado: (2020)

Vitamin D Deficiency Prevalence and Predictors in Early Pregnancy among Arab Women
por: Al-Musharaf, Sara, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_u251t527ffio5vpamq0hdc6cjr