Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

BACKGROUND: Human apolipoprotein E (apoE) exists in three major isoforms: apoE2, apoE3 and apoE4. In the brain, apoE is produced mostly by astrocytes and transports cholesterol to neurons via apoE receptors. Among the gene alleles encoding the three isoforms, the APOE4 allele is the strongest geneti...

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Detalles Bibliográficos
Autores principales: Hu, Jin, Liu, Chia-Chen, Chen, Xiao-Fen, Zhang, Yun-wu, Xu, Huaxi, Bu, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356137/
https://www.ncbi.nlm.nih.gov/pubmed/25871773
http://dx.doi.org/10.1186/s13024-015-0001-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356137/
https://www.ncbi.nlm.nih.gov/pubmed/25871773
http://dx.doi.org/10.1186/s13024-015-0001-3

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