Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts

Mutations in PARK2, encoding Parkin, cause an autosomal recessive form of juvenile Parkinson Disease (JPD). The aim of the present study was to investigate the impact of PARK2 mutations on mitochondrial function and morphology in human skin fibroblasts. We analyzed cells obtained from four patients...

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Detalles Bibliográficos
Autores principales: Zanellati, Maria C., Monti, Valentina, Barzaghi, Chiara, Reale, Chiara, Nardocci, Nardo, Albanese, Alberto, Valente, Enza M., Ghezzi, Daniele, Garavaglia, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356157/
https://www.ncbi.nlm.nih.gov/pubmed/25815004
http://dx.doi.org/10.3389/fgene.2015.00078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356157/
https://www.ncbi.nlm.nih.gov/pubmed/25815004
http://dx.doi.org/10.3389/fgene.2015.00078

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