Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove

Many components of epithelial polarity protein complexes possess PDZ domains that are required for protein interaction and recruitment to the apical plasma membrane. Apical localization of the Crumbs (Crb) transmembrane protein requires a PDZ-mediated interaction with Pals1 (protein-associated with...

Descripción completa

Detalles Bibliográficos
Autores principales: Ivanova, Marina E., Fletcher, Georgina C., O’Reilly, Nicola, Purkiss, Andrew G., Thompson, Barry J., McDonald, Neil Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356366/
https://www.ncbi.nlm.nih.gov/pubmed/25760605
http://dx.doi.org/10.1107/S139900471402776X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356366/
https://www.ncbi.nlm.nih.gov/pubmed/25760605
http://dx.doi.org/10.1107/S139900471402776X

Ejemplares similares