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T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor
Hedgehog signaling is primarily transduced by two transcription factors: Gli2, which mainly acts as a full-length activator, and Gli3, which tends to be proteolytically processed from a full-length form (Gli3(FL)) to an N-terminal repressor (Gli3(REP)). Recent studies using a Sufu knockout mouse hav...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356511/ https://www.ncbi.nlm.nih.gov/pubmed/25760946 http://dx.doi.org/10.1371/journal.pone.0119455 |