Cargando…

Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense

BACKGROUND: Reactive oxygen species (ROS) are largely considered to be pathogenic to normal endothelial function in disease states such as sepsis. We hypothesized that Angiopoietin-1 (Angpt-1), an endogenous agonist of the endothelial-specific receptor, Tie-2, promotes barrier defense by activating...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghosh, Chandra C., Mukherjee, Aditi, David, Sascha, Milam, Katelyn E., Hunter, Jon T., Parikh, Samir M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356555/ https://www.ncbi.nlm.nih.gov/pubmed/25761062 http://dx.doi.org/10.1371/journal.pone.0119577

Ejemplares similares

Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis
por: Retzlaff, Jennifer, et al.
Publicado: (2017)

Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro
por: Wang, Shan, et al.
Publicado: (2014)

Exercise Training Attenuates Upregulation of p47(phox) and p67(phox) in Hearts of Diabetic Rats
por: Sharma, Neeru M., et al.
Publicado: (2016)

Colitis susceptibility in p47(phox−/−) mice is mediated by the microbiome
por: Falcone, E. Liana, et al.
Publicado: (2016)

p47phox contributes to albuminuria and kidney fibrosis in mice
por: Wang, Hongtao, et al.
Publicado: (2015)

Postsynaptic p47phox regulates long-term depression in the hippocampus
por: Yi, Jee Hyun, et al.
Publicado: (2018)

Chemical synthesis of a reported p47phox/p22phox inhibitor and characterization of its instability and irreproducible activity
por: Zang, Jie, et al.
Publicado: (2023)

ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes
por: Tlili, Asma, et al.
Publicado: (2023)

Gene transfer and expression in human neutrophils. The phox homology domain of p47(phox )translocates to the plasma membrane but not to the membrane of mature phagosomes
por: Johnson, Jennifer L, et al.
Publicado: (2006)

The p47phox mouse knock-out model of chronic granulomatous disease
Publicado: (1995)

New NADPH Oxidase 2 Inhibitors Display Potent Activity against Oxidative Stress by Targeting p22(phox)-p47(phox) Interactions
por: Treuer, Adriana V., et al.
Publicado: (2023)

HSCARG Inhibits NADPH Oxidase Activity through Regulation of the Expression of p47phox
por: Xiao, Weichun, et al.
Publicado: (2013)

Novel PKC-ζ to p47(phox) interaction is necessary for transformation from blebbishields
por: Jinesh, Goodwin G., et al.
Publicado: (2016)

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox
Publicado: (1994)

Ethers and esters derived from apocynin avoid the interaction between p47phox and p22phox subunits of NADPH oxidase: evaluation in vitro and in silico
por: Macías-Pérez, Martha Edith, et al.
Publicado: (2013)

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS
por: Parikh, Samir M
Publicado: (2013)

Role of p40(phox) in host defense against Citrobacter rodentium infection
por: Yan, Yanyun, et al.
Publicado: (2021)

Molecular Insights of p47(phox) Phosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production
por: Meijles, Daniel N., et al.
Publicado: (2014)

Novel Diagnostic Tool for p47(phox)-Deficient Chronic Granulomatous Disease Patient and Carrier Detection
por: Wrona, Dominik, et al.
Publicado: (2019)

p47(phox) deficiency improves cognitive impairment and attenuates tau hyperphosphorylation in mouse models of AD
por: Gong, Ping, et al.
Publicado: (2020)

Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils
por: Ohayon, Delphine, et al.
Publicado: (2019)

p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis
por: Wang, Xiamin, et al.
Publicado: (2020)

P47(phox−/−) Mice Are Compromised in Expansion and Activation of CD8(+) T Cells and Susceptible to Trypanosoma cruzi Infection
por: Dhiman, Monisha, et al.
Publicado: (2014)

Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer
por: Richter, Cornelia, et al.
Publicado: (2017)

oxLDL-mediated cellular senescence is associated with increased NADPH oxidase p47phox recruitment to caveolae
por: Wang, Jing, et al.
Publicado: (2018)

Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils
por: Ohayon, Delphine, et al.
Publicado: (2019)

PP2A-dependent control of transcriptionally active FOXO3a in CD8(+) central memory lymphocyte survival requires p47(phox)
por: Liu, Q, et al.
Publicado: (2012)

Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function
por: Rokhzan, Ramin, et al.
Publicado: (2018)

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
por: Sylvers-Davie, Kelli L., et al.
Publicado: (2021)

A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis
por: Wang, Zi-Chao, et al.
Publicado: (2022)

Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells
por: Efimova, Olga, et al.
Publicado: (2011)

Zinc Oxide Nanoparticles Induce Necrosis and Apoptosis in Macrophages in a p47phox- and Nrf2-Independent Manner
por: Wilhelmi, Verena, et al.
Publicado: (2013)

NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse
por: Xu, Fang, et al.
Publicado: (2015)

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice
por: Rezende, Flávia, et al.
Publicado: (2017)

Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst Production of Reactive Oxygen Species and Neural Toxicity
por: Li, Yu-jie, et al.
Publicado: (2017)

Lentiviral gene therapy rescues p47(phox) chronic granulomatous disease and the ability to fight Salmonella infection in mice
por: Schejtman, Andrea, et al.
Publicado: (2020)

From Angiopoietin-2 to basic chemistry: differential effects of statins on endothelial homeostasis in ARDS
por: Hofmaenner, Daniel A., et al.
Publicado: (2023)

Lipoxin A4 attenuates uric acid-activated, NADPH oxidase-dependent oxidative stress by interfering with translocation of p47phox in human umbilical vein endothelial cells
por: Zhou, You, et al.
Publicado: (2020)

Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2
por: Nguyen, Vicky PKH, et al.
Publicado: (2007)

Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia
por: Yang, Chul-Su, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_7ahp31k64jlbn82smbbb5ngko7