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Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense

BACKGROUND: Reactive oxygen species (ROS) are largely considered to be pathogenic to normal endothelial function in disease states such as sepsis. We hypothesized that Angiopoietin-1 (Angpt-1), an endogenous agonist of the endothelial-specific receptor, Tie-2, promotes barrier defense by activating...

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Detalles Bibliográficos
Autores principales:	Ghosh, Chandra C., Mukherjee, Aditi, David, Sascha, Milam, Katelyn E., Hunter, Jon T., Parikh, Samir M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356555/ https://www.ncbi.nlm.nih.gov/pubmed/25761062 http://dx.doi.org/10.1371/journal.pone.0119577

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