TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells

Complex ganglioside expression is highly deregulated in several tumors which is further dependent on specific ganglioside synthase genes. Here, we designed and constructed a pair of highly specific transcription-activator like effector endonuclease (TALENs) to disrupt a particular genomic locus of m...

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Detalles Bibliográficos
Autores principales: Mahata, Barun, Banerjee, Avisek, Kundu, Manjari, Bandyopadhyay, Uday, Biswas, Kaushik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357006/
https://www.ncbi.nlm.nih.gov/pubmed/25762467
http://dx.doi.org/10.1038/srep09048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357006/
https://www.ncbi.nlm.nih.gov/pubmed/25762467
http://dx.doi.org/10.1038/srep09048

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