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Effect of plasmid replication deregulation via inc mutations on E. coli proteome & simple flux model analysis

When the replication of a plasmid based on sucrose selection is deregulated via the inc1 and inc2 mutations, high copy numbers (7,000 or greater) are attained while the growth rate on minimal medium is negligibly affected. Adaptions were assumed to be required in order to sustain the growth rate. Pr...

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Detalles Bibliográficos
Autores principales: Meade, Jonathan, Bartlow, Patrick, Trivedi, Ram Narayan, Akhtar, Parvez, Ataai, Mohammad M, Khan, Saleem A, Domach, Michael M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357208/
https://www.ncbi.nlm.nih.gov/pubmed/25890349
http://dx.doi.org/10.1186/s12934-015-0212-x