Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity

The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells. Thus, they play an essential role in tumour cells that are usually highly glycolytic and are promising targets for anti-cancer drugs. AR-C155858 is a potent MCT1 inhibito...

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Detalles Bibliográficos
Autores principales: Nancolas, Bethany, Sessions, Richard B., Halestrap, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357239/
https://www.ncbi.nlm.nih.gov/pubmed/25437897
http://dx.doi.org/10.1042/BJ20141223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357239/
https://www.ncbi.nlm.nih.gov/pubmed/25437897
http://dx.doi.org/10.1042/BJ20141223

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