Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis

Glypican-3 is a cell surface glycoprotein that associates with Wnt in liver cancer. We develop two antibodies targeting glypican-3, HN3 and YP7. The first antibody recognizes a functional epitope and inhibits Wnt signaling, whereas the second antibody recognizes a C-terminal epitope but does not inh...

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Detalles Bibliográficos
Autores principales: Gao, Wei, Tang, Zhewei, Zhang, Yifan, Feng, Mingqian, Qian, Min, Dimitrov, Dimiter S., Ho, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357278/
https://www.ncbi.nlm.nih.gov/pubmed/25758784
http://dx.doi.org/10.1038/ncomms7536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357278/
https://www.ncbi.nlm.nih.gov/pubmed/25758784
http://dx.doi.org/10.1038/ncomms7536

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