TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I inteferons, which induce the transcription of various antiviral genes called interferon stimulated genes (ISGs) to eliminate viral infection. IRF3 activation requires phosphorylation, dimerizatio...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Zhao, Wei, Zhao, Kai, Zhang, Lei, Gao, Chengjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357427/
https://www.ncbi.nlm.nih.gov/pubmed/25763818
http://dx.doi.org/10.1371/journal.ppat.1004726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357427/
https://www.ncbi.nlm.nih.gov/pubmed/25763818
http://dx.doi.org/10.1371/journal.ppat.1004726

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