Cargando…
On the Role of Protein Disulfide Isomerase in the Retrograde Cell Transport of Secreted Phospholipases A(2)
Following the finding that ammodytoxin (Atx), a neurotoxic secreted phospholipase A(2) (sPLA(2)) in snake venom, binds specifically to protein disulfide isomerase (PDI) in vitro we show that these proteins also interact in living rat PC12 cells that are able to internalize this group IIA (GIIA) sPLA...
Autores principales: | Oberčkal, Jernej, Kovačič, Lidija, Šribar, Jernej, Leonardi, Adrijana, Dolinar, Klemen, Pucer Janež, Anja, Križaj, Igor |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357439/ https://www.ncbi.nlm.nih.gov/pubmed/25763817 http://dx.doi.org/10.1371/journal.pone.0120692 |
Ejemplares similares
-
The neurotoxic secreted phospholipase A(2) from the Vipera a. ammodytes venom targets cytochrome c oxidase in neuronal mitochondria
por: Šribar, Jernej, et al.
Publicado: (2019) -
Rat Group IIA Secreted Phospholipase A(2) Binds to Cytochrome c Oxidase and Inhibits Its Activity: A Possible Episode in the Development of Alzheimer’s Disease
por: Ivanušec, Adrijan, et al.
Publicado: (2022) -
Secreted Phospholipases A(2) - not just Enzymes: Revisited
por: Ivanušec, Adrijan, et al.
Publicado: (2022) -
The Phospholipase Activity of Ammodytoxin, a Prototype Snake Venom β-Neurotoxin, Is Not Obligatory for Cell Internalisation and Translocation to Mitochondria
por: Ivanušec, Adrijan, et al.
Publicado: (2022) -
Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration
por: Zottel, Alja, et al.
Publicado: (2020)