Tool Compounds Robustly Increase Turnover of an Artificial Substrate by Glucocerebrosidase in Human Brain Lysates

Mutations in glucocerebrosidase (GBA1) cause Gaucher disease and also represent a common risk factor for Parkinson’s disease and Dementia with Lewy bodies. Recently, new tool molecules were described which can increase turnover of an artificial substrate 4MUG when incubated with mutant N370S GBA1 fr...

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Detalles Bibliográficos
Autores principales: Berger, Zdenek, Perkins, Sarah, Ambroise, Claude, Oborski, Christine, Calabrese, Matthew, Noell, Stephen, Riddell, David, Hirst, Warren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357465/
https://www.ncbi.nlm.nih.gov/pubmed/25763858
http://dx.doi.org/10.1371/journal.pone.0119141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357465/
https://www.ncbi.nlm.nih.gov/pubmed/25763858
http://dx.doi.org/10.1371/journal.pone.0119141

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