Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms

General control nonderepressible kinase 2 (GCN2) is a promising target for cancer therapy. However, the role of GCN2 in cancer cell survival or death is elusive; further, small molecules targeting GCN2 signaling are not available. By using a GCN2 level-based drug screening assay, we found that GCN2...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Chen, Lin, Ma, Jinjun, Bian, Su, Feng, Dan, Cao, Yan, Chen, Jie, Yang, Jin, Zhang, Zi-Chun, Hua, Wu, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357505/
https://www.ncbi.nlm.nih.gov/pubmed/25589675
http://dx.doi.org/10.1091/mbc.E14-10-1438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357505/
https://www.ncbi.nlm.nih.gov/pubmed/25589675
http://dx.doi.org/10.1091/mbc.E14-10-1438

Ejemplares similares