G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

We recently identified a novel GPCR-dependent pathway for regulation of cardiac hypertrophy that depends on Golgi phosphatidylinositol 4-phosphate (PI4P) hydrolysis by a specific isoform of phospholipase C (PLC), PLCε, at the nuclear envelope. How stimuli are transmitted from cell surface GPCRs to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Malik, S., deRubio, R. G., Trembley, M., Irannejad, R., Wedegaertner, P. B., Smrcka, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357516/
https://www.ncbi.nlm.nih.gov/pubmed/25609085
http://dx.doi.org/10.1091/mbc.E14-10-1476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357516/
https://www.ncbi.nlm.nih.gov/pubmed/25609085
http://dx.doi.org/10.1091/mbc.E14-10-1476

Ejemplares similares