Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

BACKGROUND: Carvedilol (CVD) is used for the treatment of essential hypertension, heart failure, and systolic dysfunction after myocardial infarction. Due to its lower aqueous solubility and extensive first-pass metabolism, the absolute bioavailability of CVD does not exceed 30%. To overcome these d...

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Detalles Bibliográficos
Autores principales: Aljimaee, Yazeed HM, El-Helw, Abdel-Rahim M, Ahmed, Osama AA, El-Say, Khalid M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357615/
https://www.ncbi.nlm.nih.gov/pubmed/25834396
http://dx.doi.org/10.2147/DDDT.S80294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357615/
https://www.ncbi.nlm.nih.gov/pubmed/25834396
http://dx.doi.org/10.2147/DDDT.S80294

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