Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages

Although the RNase H-dependent mechanism of inhibition of gene expression by chemically modified antisense oligonucleotides (ASOs) has been well characterized, little is known about the interactions between ASOs and intracellular proteins that may alter cellular localization and/or potency of ASOs....

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Detalles Bibliográficos
Autores principales: Liang, Xue-hai, Sun, Hong, Shen, Wen, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357732/
https://www.ncbi.nlm.nih.gov/pubmed/25712094
http://dx.doi.org/10.1093/nar/gkv143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357732/
https://www.ncbi.nlm.nih.gov/pubmed/25712094
http://dx.doi.org/10.1093/nar/gkv143

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