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Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages
Although the RNase H-dependent mechanism of inhibition of gene expression by chemically modified antisense oligonucleotides (ASOs) has been well characterized, little is known about the interactions between ASOs and intracellular proteins that may alter cellular localization and/or potency of ASOs....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357732/ https://www.ncbi.nlm.nih.gov/pubmed/25712094 http://dx.doi.org/10.1093/nar/gkv143 |