How lamina-associated polypeptide 1 (LAP1) activates Torsin

Lamina-associated polypeptide 1 (LAP1) resides at the nuclear envelope and interacts with Torsins, poorly understood endoplasmic reticulum (ER)-localized AAA+ ATPases, through a conserved, perinuclear domain. We determined the crystal structure of the perinuclear domain of human LAP1. LAP1 possesses...

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Detalles Bibliográficos
Autores principales: Sosa, Brian A, Demircioglu, F Esra, Chen, James Z, Ingram, Jessica, Ploegh, Hidde L, Schwartz, Thomas U
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358337/
https://www.ncbi.nlm.nih.gov/pubmed/25149450
http://dx.doi.org/10.7554/eLife.03239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358337/
https://www.ncbi.nlm.nih.gov/pubmed/25149450
http://dx.doi.org/10.7554/eLife.03239

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