A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native microenvironment. Specifically, we identified ma...

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Detalles Bibliográficos
Autores principales: Meacham, Corbin E., Lawton, Lee N., Soto-Feliciano, Yadira M., Pritchard, Justin R., Joughin, Brian A., Ehrenberger, Tobias, Fenouille, Nina, Zuber, Johannes, Williams, Richard T., Young, Richard A., Hemann, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358400/
https://www.ncbi.nlm.nih.gov/pubmed/25737277
http://dx.doi.org/10.1101/gad.254151.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358400/
https://www.ncbi.nlm.nih.gov/pubmed/25737277
http://dx.doi.org/10.1101/gad.254151.114

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