Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library

[Image: see text] α-Conotoxins are disulfide-rich peptide neurotoxins that selectively inhibit neuronal nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR subtype has been identified as a novel target for managing nicotine addiction. Using a mixture-based positional-scanning synthetic combin...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Yi-Pin, Banerjee, Jayati, Dowell, Cheryl, Wu, Jinhua, Gyanda, Reena, Houghten, Richard A., Toll, Lawrence, McIntosh, J. Michael, Armishaw, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358631/
https://www.ncbi.nlm.nih.gov/pubmed/24649848
http://dx.doi.org/10.1021/jm500183r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358631/
https://www.ncbi.nlm.nih.gov/pubmed/24649848
http://dx.doi.org/10.1021/jm500183r

Ejemplares similares