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Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library

[Image: see text] α-Conotoxins are disulfide-rich peptide neurotoxins that selectively inhibit neuronal nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR subtype has been identified as a novel target for managing nicotine addiction. Using a mixture-based positional-scanning synthetic combin...

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Detalles Bibliográficos
Autores principales:	Chang, Yi-Pin, Banerjee, Jayati, Dowell, Cheryl, Wu, Jinhua, Gyanda, Reena, Houghten, Richard A., Toll, Lawrence, McIntosh, J. Michael, Armishaw, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358631/ https://www.ncbi.nlm.nih.gov/pubmed/24649848 http://dx.doi.org/10.1021/jm500183r

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