Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

Mutations in the splicing factor SF3B1 are found in several cancer types and have been associated with various splicing defects. Using transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of cryptic 3’ splice sites (3’...

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Detalles Bibliográficos
Autores principales: DeBoever, Christopher, Ghia, Emanuela M., Shepard, Peter J., Rassenti, Laura, Barrett, Christian L., Jepsen, Kristen, Jamieson, Catriona H. M., Carson, Dennis, Kipps, Thomas J., Frazer, Kelly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358997/
https://www.ncbi.nlm.nih.gov/pubmed/25768983
http://dx.doi.org/10.1371/journal.pcbi.1004105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358997/
https://www.ncbi.nlm.nih.gov/pubmed/25768983
http://dx.doi.org/10.1371/journal.pcbi.1004105

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