Cargando…

Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

Mutations in the splicing factor SF3B1 are found in several cancer types and have been associated with various splicing defects. Using transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of cryptic 3’ splice sites (3’...

Descripción completa

Detalles Bibliográficos
Autores principales:	DeBoever, Christopher, Ghia, Emanuela M., Shepard, Peter J., Rassenti, Laura, Barrett, Christian L., Jepsen, Kristen, Jamieson, Catriona H. M., Carson, Dennis, Kipps, Thomas J., Frazer, Kelly A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358997/ https://www.ncbi.nlm.nih.gov/pubmed/25768983 http://dx.doi.org/10.1371/journal.pcbi.1004105

Ejemplares similares

Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments
por: Smith, Erin N, et al.
Publicado: (2014)

Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy
por: Barrett, Christian L., et al.
Publicado: (2015)

Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia
por: Schwaederlé, M, et al.
Publicado: (2013)

Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development
por: Smith, E N, et al.
Publicado: (2015)

Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism
por: Hasan, Md Kamrul, et al.
Publicado: (2020)

Cancer associated SF3B1 mutants recognize otherwise inaccessible cryptic 3’ splice sites within RNA secondary structures
por: Kesarwani, Anil K., et al.
Publicado: (2016)

The SF3b complex: splicing and beyond
por: Sun, Chengfu
Publicado: (2020)

Whole Transcriptome Sequencing Enables Discovery and Analysis of Viruses in Archived Primary Central Nervous System Lymphomas
por: DeBoever, Christopher, et al.
Publicado: (2013)

Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes
por: Dolatshad, H, et al.
Publicado: (2016)

High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia
por: Ghia, Emanuela M., et al.
Publicado: (2022)

MiningABs: mining associated biomarkers across multi-connected gene expression datasets
por: Cheng, Chun-Pei, et al.
Publicado: (2014)

Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells
por: Yu, J, et al.
Publicado: (2017)

Cryptic splice sites and split genes
por: Kapustin, Yuri, et al.
Publicado: (2011)

Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia
por: Rassenti, Laura Z., et al.
Publicado: (1997)

Biased exon/intron distribution of cryptic and de novo 3′ splice sites
por: Královičová, Jana, et al.
Publicado: (2005)

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
por: Harbour, J. William, et al.
Publicado: (2013)

Transcriptome Sequencing of Tumor Subpopulations Reveals a Spectrum of Therapeutic Options for Squamous Cell Lung Cancer
por: Barrett, Christian L., et al.
Publicado: (2013)

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
por: Moon, Heegyum, et al.
Publicado: (2019)

Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex
por: O’Connor, Brian P., et al.
Publicado: (2015)

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators
por: Qiu, Jinsong, et al.
Publicado: (2016)

U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors
por: Urabe, Veronica K., et al.
Publicado: (2021)

Ambiguity about Splicing Factor 3b Subunit 3 (SF3B3) and Sin3A Associated Protein 130 (SAP130)
por: Metselaar, Paula I., et al.
Publicado: (2021)

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
por: Effenberger, Kerstin A., et al.
Publicado: (2016)

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing
por: Choi, Namjeong, et al.
Publicado: (2020)

SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52
por: Diao, Yuchao, et al.
Publicado: (2022)

A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing
por: Isaac, Roi, et al.
Publicado: (2022)

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF
por: Chen, Zhiqi, et al.
Publicado: (2010)

Genetic ancestry of participants in the National Children’s Study
por: Smith, Erin N, et al.
Publicado: (2014)

SF3B1 mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia
por: López-Oreja, Irene, et al.
Publicado: (2023)

Identification of a MIP mutation that activates a cryptic acceptor splice site in the 3′ untranslated region
por: Jin, Chongfei, et al.
Publicado: (2010)

Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1
por: Nameki, Nobukazu, et al.
Publicado: (2022)

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
por: Alsafadi, Samar, et al.
Publicado: (2016)

Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation
por: Pellacani, Claudia, et al.
Publicado: (2018)

Overlapping roles of spliceosomal components SF3B1 and PHF5A in rice splicing regulation
por: Butt, Haroon, et al.
Publicado: (2021)

The splicing factor SF3B4 drives proliferation and invasion in cervical cancer by regulating SPAG5
por: Li, Yingwei, et al.
Publicado: (2022)

Hypoparathyroidism, deafness and renal dysplasia syndrome caused by a GATA3 splice site mutation leading to the activation of a cryptic splice site
por: Gonçalves, Catarina I., et al.
Publicado: (2023)

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
por: Panzeri, Valentina, et al.
Publicado: (2023)

Splicing factor SF3B3, a NS5-binding protein, restricts ZIKV infection by targeting GCH1
por: Chen, Tanxiu, et al.
Publicado: (2022)

Quantitative analysis of cryptic splicing associated with TDP-43 depletion
por: Humphrey, Jack, et al.
Publicado: (2017)

Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers
por: Alsafadi, Samar, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p0so03l7f71lh981bfgfa6d45d