Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

Tau is an intrinsically disordered protein (IDP) whose primary physiological role is to stabilize microtubules in neuronal axons at all stages of development. In Alzheimer's and other tauopathies, tau forms intracellular insoluble amyloid aggregates known as neurofibrillary tangles, a process t...

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Detalles Bibliográficos
Autores principales: Zhu, Shaolong, Shala, Agnesa, Bezginov, Alexandr, Sljoka, Adnan, Audette, Gerald, Wilson, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359001/
https://www.ncbi.nlm.nih.gov/pubmed/25767879
http://dx.doi.org/10.1371/journal.pone.0120416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359001/
https://www.ncbi.nlm.nih.gov/pubmed/25767879
http://dx.doi.org/10.1371/journal.pone.0120416

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