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Decreased Peritoneal Ovarian Cancer Growth in Mice Lacking Expression of Lipid Phosphate Phosphohydrolase 1

Lysophosphatidic acid (LPA) is a bioactive lipid that enhances ovarian cancer cell proliferation, migration and invasion in vitro and stimulates peritoneal metastasis in vivo. LPA is generated through the action of autotaxin or phospholipases, and degradation begins with lipid phosphate phosphohydro...

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Detalles Bibliográficos
Autores principales: Nakayama, John, Raines, Timothy A., Lynch, Kevin R., Slack-Davis, Jill K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359083/
https://www.ncbi.nlm.nih.gov/pubmed/25769037
http://dx.doi.org/10.1371/journal.pone.0120071